Hydralazine Pharmacology

Hydralazine Pharmacology

Hydralazine Pharmacology

Hydralazine works as a direct vasodilator. It primarily works on the arterioles versus the venous system.

Hydralazine can cause a unique adverse reaction. It can cause a Lupus type syndrome that can result in fever, myopathy and symptoms that mimic arthritis.

I discuss drug interactions with hydralazine and how you need to be aware of certain medications that can have additive effects and also those that can oppose the effects of the drug.

One of the downsides to using hydralazine is that patients don’t like to take it as often as it requires. It is typically dosed three to four times per day.

Orthostasis is a risk with any drug that reduces blood pressure and hydralazine is no different.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Clonidine Pharmacology

Clonidine is classified as an antihypertensive. Clonidine pharmacology involves having agonist activity at central alpha 2 receptors. This leads to lower sympathetic outflow and a reduction in blood pressure.

Clonidine has numerous reported uses in addition to its antihypertensive effect. It can potentially be used for ADHD, menopausal type symptoms, and opioid withdrawal.

Clonidine has historically been on the Beers’ list of drugs as it can cause some CNS side effects like sedation, dizziness, and rarely delirium.

Clonidine is unique in the antihypertensive class as it does have a patch formulation.

Because of the blood pressure lowering effect of clonidine, we have to be aware of patients who report dizziness. Monitoring is critical.

Clonidine can also lower heart rate and contribute to dry mouth. Keep an eye out for drugs that can have a cumulative effect on these symptoms.

Drugs like beta-blockers, non-DHP CCB’s, and digoxin can all have a cumulative effect with clonidine and lower pulses. Monitoring is important.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Loop Diuretics Pharmacology

On this episode, I cover common loop diuretics. They include furosemide, torsemide, and bumetanide.

Loop diuretics are potent agents that can help in the management of heart failure and ascites.

Loops diuretics help promote the loss of excessive fluid through the urine.

A common patient complaint from loop diuretics is that they can cause frequent urination. Because of this, we typically dose these drugs earlier in the day.

Kidney function and electrolyte monitoring is critical with the use of loop diuretics.

Enjoy the episode!

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Aldosterone Antagonist Pharmacology RLP Episode 030

On today’s episode, I discuss spironolactone and eplerenone.  We cover the mechanism of action, monitoring parameters, adverse effects, and of course notable drug interactions.  Enjoy the show and please take advantage of our FREE giveaway by following the podcast via email!

Thiazide and Thiazide Like Diuretics RLP Episode 24

Thiazide diuretics are well-known to help with edema and hypertension.

Thiazides need to monitored for electrolyte imbalances. Hypokalemia is a real and significant possibility.

Thiazide diuretics can also raise uric acid which can impact our patients with gout. Pay attention to use in this patient population.

I also cover drug interactions and the mechanism of action of thiazide diuretics on this episode.

Enjoy the show!

Alpha Blockers Pharmacology RLP Episode 017

On this episode, I discuss the pharmacology and side effects of alpha blockers as well as the differences between a selective alpha blocker versus a non-selective alpha blocker. Enjoy!

All subscribers to the website/podcast will get access to a FREE Top 200 Drug Study Guide where I highlight the 3 most highly testable pearls from each medication (this is a 31 page PDF!)  In addition, you’ll get a free 100 question pharmacology test.  Both resources are free, simply for following the podcast!  What are you waiting for? Click Here to Subscribe

DHP Calcium Channel Blockers RLP Episode – 012

On this episode, I discuss the pharmacology of calcium channel blockers.  There is a few common side effects with these medications and they can lead to the prescribing cascade.  I talk about an example in the podcast where they can cause edema which leads to a prescription for a diuretic.  I also talk about a really common drug interaction.  Hope you enjoy the episode, and please feel free to reach out with comments and questions!

All subscribers to the website/podcast will get access to a FREE Top 200 Drug Study Guide where I highlight the 3 most highly testable pearls from each medication (this is a 31 page PDF!)  In addition, you’ll get a free 100 question pharmacology test.  Both resources are free, simply for following the podcast!  What are you waiting for? Click Here to Subscribe

Beta-Blockers Pharmacology – Episode 004

Beta-blockers are commonly used in the management of hypertension as well as rate control for atrial fibrillation.  On this episode, I breakdown some of the most common agent and what to look out for.  Enjoy the show!

All subscribers to the website/podcast will get access to a FREE Top 200 Drug Study Guide where I highlight the 3 most highly testable pearls from each medication (this is a 31 page PDF!)  In addition, you’ll get a free 100 question pharmacology test.  Both resources are free, simply for following the podcast!  What are you waiting for? Click Here to Subscribe

Lisinopril Pharmacology – Episode 003

In the episode, I break down the pharmacology of lisinopril (and all ACE inhibitors).  I also outline common adverse effects, drug interactions and its role in managing hypertension.  Hope you enjoy the show and please feel free to reach out with feedback!

All subscribers to the website/podcast will get access to a FREE Top 200 Drug Study Guide where I highlight the 3 most highly testable pearls from each medication (this is a 31 page PDF!)  In addition, you’ll get a free 100 question pharmacology test.  Both resources are free, simply for following the podcast!  What are you waiting for? Click Here to Subscribe