Lisdexamfetamine Pharmacology Podcast

On this podcast episode, I discuss lisdexamfetamine (Vyvanse) pharmacology, adverse effects, drug interactions, and much more.

Lisdexamfetamine is a stimulant medication that is used in the management of ADHD.

Stimulants like lisdexamfetamine can increase heart rate, raise blood pressure, and suppress appetite.

Lisdexamfetamine is a schedule 2 controlled substance and has a high potential for abuse and dependence.

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Dextroamphetamine Pharmacology Podcast

On this podcast episode, I discuss dextroamphetamine’s pharmacology, adverse effects, drug interactions, and much more!

Dextroamphetamine is a stimulant medication. Weight loss, insomnia, tachycardia, and hypertension are all possible complications.

There is a patch dosage form of dextroamphetamine available called Xelstrym. I discuss it on this episode.

Vitamin C can reduce GI absorption of dextroamphetamine due to its ability to increase the acidity of the GI tract.

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Risperidone Pharmacology Podcast

On this episode, I discuss risperidone pharmacology, adverse effects, monitoring, and common indications.

There are numerous drug interactions that I discuss in this podcast episode. CYP2D6 inhibitors may increase drug concentrations.

Risperidone increases prolactin more than most 2nd generation antipsychotics. This can lead to sexual adverse effects.

QTC prolongation is a concern with all antipsychotics like risperidone. We can monitor EKG to monitor for this risk.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

Vortioxetine Pharmacology Podcast

On this podcast episode, I discuss vortioxetine pharmacology, adverse effects, drug interactions, and much more.

Because of vortioxetine’s long half-life, antidepressant discontinuation syndrome is going to be less prominent compared to ADPs with shorter half-lives.

Vortioxetine is metabolized by CYP2D6. Drugs that inhibit this enzyme will likely raise concentrations and place the patient more at risk for adverse effects.

I discuss rare vortioxetine adverse effects like hyponatremia and bleeding in this podcast episode.

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Haloperidol (Haldol) Pharmacology Podcast

On this episode of the Real Life Pharmacology podcast, I discuss haloperidol pharmacology, adverse effects, drug interactions and much more.

Haloperidol comes in multiple dosage forms. Be very careful with the use of injectable haloperidol as there is an immediate and extended release formulation.

Haloperidol is a dopamine antagonist which means that EPS adverse effects are going to be concerning.

In hospice patients, haloperidol is frequently used for its antiemetic properties as well as its potential to help end-of-life restlessness and agitation.

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Ramelteon (Rozerem) Pharmacology Podcast

On this episode, I discuss the pharmacology, adverse effects, and drug interactions of ramelteon (Rozerem).

Ramelteon is primarily only helpful for sleep onset and generally is not that helpful in sleep maintenance.

CNS depressant drug interactions will be a common concern to monitor. Opioids, benzodiazepines, and alcohol are common sedatives that can add to the effects of ramelteon.

Some of the CYP enzymes break down Ramelteon. I discuss this in greater length in this podcast episode.

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Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

Prazosin (Minipress) Pharmacology Podcast

On this episode, I discuss prazosin pharmacology, adverse effects, drug interactions and much more.

Prazosin is an alpha-blocker but lacks selectivity. A reduction in blood pressure is expected, but it is notorious for causing orthostatic hypotension.

Prazosin may be used off-label for nightmares, when this is the case, you will likely only see this drug dosed at bedtime.

Alpha agonist medications (such as pseudoephedrine and ADHD stimulants) may counteract the effects of prazosin.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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Brexpiprazole (Rexulti) Pharmacology Podcast

Brexpiprazole (Rexulti) is a second generation antipsychotic. I discuss its pharmacology, adverse effects, drug interactions, and more in this podcast episode.

I like to associate brexpiprazole with aripiprazole. They have a lot of overlapping characteristics, particularly in relation to the adverse effect profile.

Brexpiprazole tends to have a low incidence of metabolic adverse effects which makes it a nice selection for patients who have diabetes, hypercholesterolemia, or who are overweight.

CYP3A4 and CYP2D6 are the two primary enzymes that break down brexpiprazole. I discuss the pharmacogenomic considerations associated with this medication.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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Drug Interactions In Primary Care (Amazing Resource for Practicing Clinicians)

Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

Lorazepam (Ativan) Pharmacology Podcast

On this podcast episode, I discuss lorazepam (Ativan) pharmacology, adverse effects, and common drug interactions.

Lorazepam has numerous dosage forms and the IV formulation does contain propylene glycol which can accumulate if it is used for longer periods of time.

There is a boxed warning for lorazepam when it is used with opioids. The risk for opioid overdose, coma, and death increases significantly.

Lorazepam is an intermediate acting benzodiazpine. It’s half-life for most adult patients is in the 12-18 hour range.

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Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

Clonazepam Pharmacology Podcast

On this podcast episode, I discuss clonazepam pharmacology, adverse effects, pharmacokinetics, and drug interactions.

Clonazepam is a benzodiazepine that enhances the activity of GABA which is an inhibitory neurotransmitter in the central nervous system.

It is important to try to avoid using benzodiazepines like clonazepam with opioids as it can increase the risk of respiratory depression and death.

Clonazepam is an intermediate-acting benzodiazepine that is only commercially available as an oral dosage form.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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Drug Interactions In Primary Care (Amazing Resource for Practicing Clinicians)

Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)