Etanercept Pharmacology Podcast

On this podcast episode, I cover etanercept pharmacology, adverse effects, drug interactions and much more.

Etanercept is classified as a DMARD but is different from older DMARDs in that it is a biologic agent and needs to be injected.

Vaccination assessment in patients is important prior to initiating etanercept due to the fact that the medication may blunt the effectiveness of the vaccines.

Immunosuppression from etanercept can lead to an increased risk for infection and malignancy.

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Pregabalin Pharmacology Podcast

On this podcast episode, I discuss (Lyrica) pregabalin pharmacology, adverse effects, drug interactions, and much more.

I compare pregabalin and gabapentin in this episode and one important difference is the percent absorption of gabapentin compared to pregabalin.

Pregabalin can exacerbate the risk of respiratory depression and overdose in patients who are taking opioids.

Pregabalin is most frequently used in practice for neuropathic pain syndromes.

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Phenobarbital Pharmacology Podcast

On this episode of the Real Life Pharmacology Podcast, I cover phenobarbital pharmacology, adverse effects, important drug interactions and much more.

Phenobarbital is an enzyme inducer. It is an inducer at CYP3A4 so this can lead to numerous drug interactions.

Phenobarbital can exacerbate the risk for opioid overdose and increase the risk for respiratory depression and death.

Phenobarbital can deplete numerous vitamins such as vitamin D, folic acid, and vitamin B12. Monitoring of these is important.

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Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

Pyridostigmine Pharmacology Podcast

I discuss Pyridostigmine Pharmacology in this podcast episode in addition to adverse effects, drug interactions, and much more!

Pyridostigmine is an acetylcholinesterase inhibitor that can be used for myasthenia gravis or orthostasis.

Pyridostigmine can blunt the effect of neuromuscular blocking agents so patients undergoing surgery should be sure to have a game plan with their surgery team.

Similar to donepezil, pyridostigmine can cause diarrhea and bradycardia.

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Gabapentin (Neurontin) Pharmacology Podcast

On this podcast episode, I discuss gabapentin (Neurontin) pharmacology, adverse effects, drug interactions, and much more!

Gabapentin’s GI absorption is a little wacky. I discuss on the podcast the clinical effects that this may have on our patients.

Renal elimination is critical to gabapentin. Worsening renal function will significantly impact the action of the drug.

CNS sedation can be a problem with gabapentin, especially in combination with other CNS depressants. I discuss this further on the podcast.

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Pramipexole (Mirapex) Pharmacology

Pramipexole (Mirapex) is a dopamine agonist that can be used in Parkinson’s disease and Restless Legs Syndrome.

Dopamine agonists like pramipexole can worsen psychiatric symptoms in some patients by causing hallucinations, and obsessive/compulsive symptoms.

Nausea, vomiting, hypotension, and fatigue are the most common adverse effects of pramipexole.

Pramipexole is primarily eliminated through the urine. I discuss how this matters clinically in greater detail in this podcast episode.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

Ropinirole Pharmacology

Ropinirole (Requip) is a dopamine agonist that can be used in Parkinson’s disease and Restless Legs Syndrome.

Dopamine agonists like ropinirole can worsen psychiatric symptoms in some patients by causing hallucinations, and obsessive/compulsive symptoms.

Nausea, vomiting, hypotension, and fatigue are the most common adverse effects of ropinirole.

Ropinirole has drug interactions with antipsychotics and CYP1A2 inhibitors. I discuss these in greater detail in this podcast episode.

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Cabergoline Pharmacology

Cabergoline is a dopamine agonist. I discuss the pharmacology, adverse effects, and drug interactions in this podcast episode.

Be on the lookout for drugs that could oppose the effects of cabergoline such as antipsychotics and metoclopramide.

Cabergoline can be used for hyperprolactinemia management and may cause adverse effects like hypotension and GI upset.

Cabergoline has a very long half-life so it is most often only dosed 1-2 times per week.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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Denosumab (Prolia) Pharmacology

On this episode, I discuss denosumab pharmacology, adverse effects, clinical pearls, and drug interactions.

Whenever I see an osteoporosis medication like denosumab used, I review the medications to ensure that we avoid medications that can cause osteoporosis.

Denosumab is often used as a potential alternative in osteoporosis management for those that cannot tolerate bisphosphonates.

We need to monitor calcium levels when using denosumab as levels can be dangerously low, especially when used in combination with other calcium lowering drugs.

Loop diuretics and cinacalcet can have additive hypocalcemia effects when used in combination with denosumab.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Drug Interactions In Primary Care (Amazing Resource for Practicing Clinicians)

Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

Hydromorphone Pharmacology

On this episode, I discuss hydromorphone pharmacology, adverse effect, and drug interactions.

I discuss the pharmacokinetics of hydromorphone and also discuss the relative potency compared to other opioids.

Hydromorphone drug interactions are mostly additive effects. Drugs that cause sedation or constipation can have additive effects on hydromorphone.

Be extremely careful with hydromorphone dosage forms. There are numerous different concentrations and strengths. I discuss this in this episode.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Drug Interactions In Primary Care (Amazing Resource for Practicing Clinicians)

Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)