Tadalafil (Cialis) Pharmacology Podcast

On this episode, I discuss tadalafil pharmacology, adverse effects, pharmacokinetics, and drug interactions.

Tadalafil has a significantly longer half-life than sildenafil. I discuss how this is going to impact a patient that may need a nitrate.

PDE-5 inhibitors like tadalafil are most commonly used for erectile dysfunction but I talk about other unique indications in the podcast.

Daily use or as-needed use of tadalafil are both acceptable options but there are some quirks you need to know with these two methods of use.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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NAPLEX Study Materials

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Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Drug Interactions In Primary Care (Amazing Resource for Practicing Clinicians)

Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

Ethinyl Estradiol

On this episode, I cover ethinyl estradiol pharmacology. This is a common component of oral contraceptives. You have to check out this free resource (with free account) from Pyrls.com/rlp which lists all the different combinations and brand names. All it takes is to simply sign up for a free account here.

Ethinyl estradiol dosing can vary. Breakthrough bleeding is a major reason why a patient might prefer a higher dose.

Blood clot risk is a real problem with ethinyl estradiol. There are numerous situations where we should avoid ethinyl estradiol and I cover them in this episode.

Be careful with enzyme inducers like carbamazepine, rifampin, etc. as they can reduce the concentrations of oral contraceptives

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Support The Podcast and Check Out These Amazing Resources!

NAPLEX Study Materials

BCPS Study Materials

BCACP Study Materials

BCGP Study Materials

BCMTMS Study Materials

Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Drug Interactions In Primary Care (Amazing Resource for Practicing Clinicians)

Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

Clomiphene Pharmacology

On this episode, I discuss clomiphene pharmacology, adverse effects, clinical practice pearls, and drug interactions.

Clomiphene is a commonly used medication to help manage female infertility.

Clomiphene is oral and relatively inexpensive compared to other agents that are used for infertility management.

Clomiphene is a SERM so you can anticipate that some patients may report vasomotor symptoms like flushing and hot flashes.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Support The Podcast and Check Out These Amazing Resources!

NAPLEX Study Materials

BCPS Study Materials

BCACP Study Materials

BCGP Study Materials

BCMTMS Study Materials

Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Drug Interactions In Primary Care (Amazing Resource for Practicing Clinicians)

Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

Conjugated Estrogens Pharmacology

Conjugated estrogens (Premarin) are most often used in the management of menopausal symptoms.

Estrogen therapy can increase the risk for breast cancer and the risk should be assessed before beginning therapy.

Blood clots are a potential consequence from the use of Premarin. Premarin can oppose the benefit of anticoagulation.

Conjugated estrogens are broken down by CYP3A4. Inhibitors may increase concentrations while inducers may reduce concentrations.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Sildenafil Pharmacology

On this episode, I discuss sildenafil pharmacology, adverse effects, and important drug interactions.

Sildenafil’s most common and concerning adverse effect is in relation to its ability to lower blood pressure. I discuss this further in the podcast.

Sildenafil can cause rare visual changes that patients should be aware of and report immediately to their pharmacist or physician.

The sildenafil nitrate interaction is essential to know. I discuss it in this podcast episode.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Medroxyprogesterone Acetate Injection Pharmacology

On this podcast episode, I cover medroxyprogesterone acetate injection pharmacology (DMPA or Depo-Provera)

Medroxyprogesterone acetate injection is given every three months for the prevention of pregnancy.

Medroxyprogesterone acetate has a boxed warning for its risk of causing low bone mineral density.

Classic enzyme inducers can cause lower concentrations of medroxyprogesterone which can potentially lead to contraceptive failure.

Examples of enzyme inducers that can lower concentrations of medroxyprogesterone include carbamazepine, phenytoin, rifampin, and some agents used in the management of HIV.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!