Category: Infectious Disease and Oncology Medications

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Cephalexin (Keflex) Pharmacology Podcast

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On this podcast episode, I discuss cephalexin pharmacology, adverse effects, drug interactions, and much more!

Penicillin allergies and cross-reactivity are common questions with regard to the use of cephalexin and I discuss this briefly in the podcast episode.

Cephalexin is a first-generation cephalosporin with its primary sweet spot being gram-positive bacteria like Staph and Strep species.

Warfarin, probenecid, zinc, and a couple of others are potential medications that can interact with cephalexin. I discuss this further in this podcast episode.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Support The Podcast and Check Out These Amazing Resources!

NAPLEX Study Materials

BCPS Study Materials

BCACP Study Materials

BCGP Study Materials

BCMTMS Study Materials

Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Drug Interactions In Primary Care (Amazing Resource for Practicing Clinicians)

Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

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Ceftriaxone Pharmacology

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On this episode, I discuss ceftriaxone pharmacology, adverse effect, coverage, and drug interactions. Ceftriaxone is currently a drug of choice for the STI Gonorrhea. Pyrls.com has an amazing chart on all the STIs and their drugs of choice that you can get for free when you sign up for a free account!

Ceftriaxone is a third-generation cephalosporin that is used for numerous indications such as pneumonia, meningitis, gonorrhea, and many more.

It is important to remember that ceftriaxone can cover many staph and strep species but it does NOT cover MRSA.

Ceftriaxone does have some risks, particularly in pediatric patients. I discuss elevated bilirubin and calcium binding risks in the podcast.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Support The Podcast and Check Out These Amazing Resources!

NAPLEX Study Materials

BCPS Study Materials

BCACP Study Materials

BCGP Study Materials

BCMTMS Study Materials

Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Drug Interactions In Primary Care (Amazing Resource for Practicing Clinicians)

Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

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Isavuconazole Pharmacology

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Isavuconazole is an azole antifungal that can be used for various fungal infections.

In this episode, I discuss isavuconazole pharmacology, adverse effect, drug interactions, and pharmacokinetics.

Isavuconazole is interestingly associated with QT shortening which is different from most azole antifungals that cause QT prolongation.

Oral bioavailability of isavuconazole is nearly 100% so dose conversions between IV and oral are typically not difficult to navigate.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Support The Podcast and Check Out These Amazing Resources!

NAPLEX Study Materials

BCPS Study Materials

BCACP Study Materials

BCGP Study Materials

BCMTMS Study Materials

Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Drug Interactions In Primary Care (Amazing Resource for Practicing Clinicians)

Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

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Doxycycline Pharmacology

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On this episode of the Real Life Pharmacology podcast, I explore doxycycline pharmacology, adverse effects, and drug interactions.

Doxycycline can be bound by numerous minerals like calcium, magnesium, and iron. Coadministration can lead to reduced concentrations.

Sun sensitivity is a really important adverse effect that can be caused by doxycycline. Be sure to educate your patients.

Doxycycline can be used as an alternative to beta-lactams and macrolides in the management of community-acquired pneumonia.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Support The Podcast and Check Out These Amazing Resources!

NAPLEX Study Materials

BCPS Study Materials

BCACP Study Materials

BCGP Study Materials

BCMTMS Study Materials

Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Drug Interactions In Primary Care (Amazing Resource for Practicing Clinicians)

Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

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Clarithromycin Pharmacology

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On this episode, I discuss clarithromycin pharmacology, adverse effects, and drug interactions.

Clarithromycin is a macrolide antibiotic that can be used for many similar indications as azithromycin.

Clarithromycin has numerous drug interactions as it can inhibit CYP3A4. This limits its use in practice.

Clarithromycin can be used in the treatment of H. pylori in combination with other antibiotics and a PPI.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Support The Podcast and Check Out These Amazing Resources!

NAPLEX Study Materials

BCPS Study Materials

BCACP Study Materials

BCGP Study Materials

BCMTMS Study Materials

Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Drug Interactions In Primary Care (Amazing Resource for Practicing Clinicians)

Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

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Rifaximin Pharmacology

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On this episode, I discuss rifaximin pharmacology.

Rifaximin is most commonly used in hepatic encephalopathy and C. difficile infection.

Rifaximin systemic absorption is minimal so that is why it is primarily only used for GI conditions.

Drug interactions with rifaximin are fairly minimal compared to its cousin rifampin which has tons of drug interactions.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Palivizumab Pharmacology

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On this episode, I discuss palivizumab pharmacology and how it is used in pediatric patients.

Palivizumab is a monoclonal antibody that is used to prevent RSV infections in pediatric patients.

Palivizumab is an IM injection that is dosed by weight. Learn more on this podcast episode.

RSV can be devastating in pediatric patients under the age of two. Palivizumab can be used in select populations to help prevent the infection.

Injection and skin reactions are possible with the use of palivizumab.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

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Fluconazole Pharmacology

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On this episode of the RLP podcast, I discuss fluconazole pharmacology.

Fluconazole prevents fungi from producing essential components for their cell membrane and thus inhibits their growth.

Drug interactions are common with fluconazole. Fluconazole inhibits CYP3A4, 2C9, and 2C19 to varying degrees.

I discuss an interaction between fluconazole and phenytoin in this podcast episode.

Hepatitis has rarely been reported with the use of azole antifungals like fluconazole.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Valacyclovir Pharmacology

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Valacyclovir can be used for various viral infections such as herpes virus and varicella.

The primary clinical advantage of valacyclovir compared to acyclovir is that it is dosed less frequently.

Valacyclovir may have some mild CYP1A2 inhibitory effect. I discuss the clinical relevance of this on this episode.

GI upset can occur so I usually recommend to give it with food even though it may be given with or without food.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

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Abacavir Pharmacology

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Abacavir is a nucleoside reverse transcriptase inhibitor used in the management of HIV.

In patients who have the HLA-B*5701 allele, they are at much greater risk for hypersensitivity reactions.

Lactic acidosis and hepatomegaly are potential complications with the use of abacavir.

While abacavir is not known for a large number of drug interactions, I discuss a few that you have a chance to run into.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!