Category: Infectious Disease and Oncology Medications

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January 11, 2024January 9, 2024

Levofloxacin Pharmacology Podcast Episode 309

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On this podcast episode, I discuss levofloxacin pharmacology, adverse effects, boxed warnings, interactions, and much more.

Levofloxacin is well known to cause QTc prolongation and many drugs can increase this risk such as antiarrhythmics, citalopram, antipsychotics, and many more.

Binding interactions are important when discussing levofloxacin pharmacology. Calcium, iron, magnesium, and many other cations can block the absorption of this medication.

I discuss tendon rupture in relation to levofloxacin use and what factors may increase the risk of this rare adverse effect.

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August 17, 2023August 9, 2023

Tamoxifen Pharmacology Podcast

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On this podcast episode, I discuss tamoxifen pharmacology, adverse effects, drug interaction, and much more.

Tamoxifen is converted to a more active compound in the body by CYP2D6.

CYP2D6 inhibitors such as paroxetine, fluoxetine, or bupropion can essentially reduce the effectiveness of tamoxifen.

Hot flashes are a common adverse effect of tamoxifen and I discuss a few pharmacologic options to manage this adverse effect.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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July 20, 2023July 14, 2023

Clindamycin Pharmacology Podcast

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On this podcast episode, I discuss clindamycin pharmacology, adverse effects, drug interactions, and much more!

Clindamycin (oral administration) can cause esophageal irritation and it is recommended to take this medication with a full glass of water.

C. Diff risk and frequent dosing are two of the biggest downsides to using clindamycin to manage infections.

Clindamycin has good activity against many gram-positive organisms like Staph and Strep as well as anaerobic activity.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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June 8, 2023June 5, 2023

Cefuroxime Pharmacology Podcast

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On this episode, I discuss cefuroxime pharmacology, adverse effects, drug interaction, pharmacokinetics, and much more.

Cefuroxime is a 2nd generation cephalosporin that binds Penicillin-binding proteins and prevents bacterial cell wall synthesis.

Medications that create a higher pH in the stomach such as antacids can ultimately reduce the concentrations of cefuroxime.

Cefuroxime is primarily eliminated by the kidney. Dose adjustments are recommended for patients with a CrCL less than 30 mls/min.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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December 22, 2022December 16, 2022

Minocycline Pharmacology Podcast

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Minocycline is a tetracycline antibiotic. I discuss pharmacology, adverse effects, and drug interactions.

Minocycline can cause sun sensitivity. Be sure to educate patients about this risk.

Metal cations like iron, zinc, calcium, and magnesium can bind minocycline and reduce the oral absorption of the medication.

Tooth discoloration is a possible adverse effect if minocycline is given to pediatric patients. I discuss it further in this episode.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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September 15, 2022November 4, 2022

Cephalexin (Keflex) Pharmacology Podcast

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On this podcast episode, I discuss cephalexin pharmacology, adverse effects, drug interactions, and much more!

Penicillin allergies and cross-reactivity are common questions with regard to the use of cephalexin and I discuss this briefly in the podcast episode.

Cephalexin is a first-generation cephalosporin with its primary sweet spot being gram-positive bacteria like Staph and Strep species.

Warfarin, probenecid, zinc, and a couple of others are potential medications that can interact with cephalexin. I discuss this further in this podcast episode.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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September 8, 2022September 8, 2022

Ceftriaxone Pharmacology

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On this episode, I discuss ceftriaxone pharmacology, adverse effect, coverage, and drug interactions. Ceftriaxone is currently a drug of choice for the STI Gonorrhea. Pyrls.com has an amazing chart on all the STIs and their drugs of choice that you can get for free when you sign up for a free account!

Ceftriaxone is a third-generation cephalosporin that is used for numerous indications such as pneumonia, meningitis, gonorrhea, and many more.

It is important to remember that ceftriaxone can cover many staph and strep species but it does NOT cover MRSA.

Ceftriaxone does have some risks, particularly in pediatric patients. I discuss elevated bilirubin and calcium binding risks in the podcast.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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August 11, 2022July 28, 2022

Isavuconazole Pharmacology

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Isavuconazole is an azole antifungal that can be used for various fungal infections.

In this episode, I discuss isavuconazole pharmacology, adverse effect, drug interactions, and pharmacokinetics.

Isavuconazole is interestingly associated with QT shortening which is different from most azole antifungals that cause QT prolongation.

Oral bioavailability of isavuconazole is nearly 100% so dose conversions between IV and oral are typically not difficult to navigate.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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November 25, 2021January 10, 2022

Doxycycline Pharmacology

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On this episode of the Real Life Pharmacology podcast, I explore doxycycline pharmacology, adverse effects, and drug interactions.

Doxycycline can be bound by numerous minerals like calcium, magnesium, and iron. Coadministration can lead to reduced concentrations.

Sun sensitivity is a really important adverse effect that can be caused by doxycycline. Be sure to educate your patients.

Doxycycline can be used as an alternative to beta-lactams and macrolides in the management of community-acquired pneumonia.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)