Lithium Pharmacology

Lithium is a drug that has a ton of clinical pearls.  On this episode, I talk about the pharmacology, side effects, drug interactions, and critical practice pearls.

Kidney function is very important to monitor in our patients taking lithium.  Lithium can accumulate in renal impairment.

Thyroid function can be altered by lithium.  Be sure to regularly monitor TSH in a patient on chronic lithium.

Over-the-counter NSAID can interact and raise lithium levels.  This is something you need to watch out for as patients can begin taking these medications on their own without supervision.

Be sure to assess lithium levels.  Signs of toxicity can include GI upset, tremor, motor movement issues, sedation, and CNS changes.

Pseudoephedrine Pharmacology

Pseudoephedrine is commonly used to help relieve nasal congestion.

There are some adverse effects you need to be aware of with pseudoephedrine. Insomnia, increase in blood pressure, and urinary retention are all possible.

When I assess a patient using pseudoephedrine, I like to investigate blood pressure, history of urinary problems and insomnia history.

Pseudoephedrine can cause the prescribing cascade.  I lay out examples in the podcast.

Pseudoephedrine should not be utilized with MAOI’s if possible – I discuss the reason for this in the podcast.

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Fentanyl Pharmacology

On this episode, I discuss fentanyl pharmacology.

I address important considerations that you must remember with fentanyl patches.

Those considerations include how pharmacokinetics can impact our patients.

I also break down common side effects of opioids as well as potential common drug interactions.

Drug diversion and illicit use is an important consideration when using fentanyl.  I also touch on this topic.

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Quinolone Antibiotic Pharmacology

Quinolones are a class of antibiotics that can be used for various infections. I discuss the pharmacology, adverse effects, drug interactions and other items on this podcast episode.

On this episode, I talk about the warnings associated with quinolones.

Quinolone use has subsided over time, not due to the fact that they are ineffective, but to rising concerns and warnings about adverse effects.

Quinolones can interact with quite a few medications.  I’ve seen a case of amiodarone and levofloxacin contributing to QTc prolongation which I discuss on this episode.

It is critical to remember the binding interactions associated with quinolones as these can potentially lead to treatment failure.

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Potassium Supplement Pharmacology

On this episode I discuss why we may need to use potassium supplements.

I also talk about a medication error situation involving potassium that lead to a death.

It is important to remember other medications that can raise potassium levels.

I also talk about a dosage form of potassium that might make patients ask some questions.

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Apixaban Pharmacology

On this episode, I talk about apixaban (Eliquis) pharmacology.

I also cover adverse effects like bleeding and what to monitor.

Drug interactions are a concern with apixaban and I discuss a few items that you may want to look out for.

It is important to remember that apixaban does require dose adjustments in certain situations as well.

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Metoclopramide (Reglan) Pharmacology

Metoclopramide Pharmacology

Metoclopramide can block dopamine receptors as part of it’s mechanism of action.  I discuss the clinical implications from this in the podcast.

Metoclopramide can exacerbate Parkison’s disorder so you need to be careful in that type of patient.

Metoclopramide is dosed frequently, which can potentially be a downside as far as patient adherence goes.

Metoclopramide has a few potential interactions that you should be aware of.  I talk about those in this episode.

Be sure to check out The Thrill of the Case on Amazon as I do have a clinical scenario about Reglan (metoclopramide) in that 200+ page book.

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SGLT-2 Inhibitors Pharmacology

On this episode, I discuss the mechanism of action of the SGLT-2 Inhibitors and how they lower blood sugar.

These drugs are classically used for diabetes and eliminate blood sugar through the urine.

One of the potential side effects is that these drugs can increase the risk of genital infections and urinary tract infections.

There is a boxed warning on canagliflozin for its potential to increase the risk of amputation.

These drugs also have a mild diuretic type effect and can potentially cause hypotension.

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Eric Christianson, PharmD, BCGP, BCPS

Tetracyclines Pharmacology Episode 038

On this episode, I discuss how the tetracyclines impact bacterial protein synthesis.

I also remind you of several medications that fall in the tetracycline class.  Doxycycline is by far the medication I see used the most.

You’ll also learn about common side effects like GI upset and photosensitivity.

I cover why this class of medication is typically avoided in pediatrics and pregnancy.

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Allopurinol Pharmacology

I break down the mechanism of action, side effects, and important drug interactions you need to know. I give you a sense of what things you might actually encounter in practice when working with patients who take allopurinol.

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I hope you enjoy this episode the pharmacology of allopurinol!