Isavuconazole Pharmacology

Isavuconazole is an azole antifungal that can be used for various fungal infections.

In this episode, I discuss isavuconazole pharmacology, adverse effect, drug interactions, and pharmacokinetics.

Isavuconazole is interestingly associated with QT shortening which is different from most azole antifungals that cause QT prolongation.

Oral bioavailability of isavuconazole is nearly 100% so dose conversions between IV and oral are typically not difficult to navigate.

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Fluconazole Pharmacology

On this episode of the RLP podcast, I discuss fluconazole pharmacology.

Fluconazole prevents fungi from producing essential components for their cell membrane and thus inhibits their growth.

Drug interactions are common with fluconazole. Fluconazole inhibits CYP3A4, 2C9, and 2C19 to varying degrees.

I discuss an interaction between fluconazole and phenytoin in this podcast episode.

Hepatitis has rarely been reported with the use of azole antifungals like fluconazole.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

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