Darifenacin Pharmacology Podcast – Episode 308

On this podcast episode, I discuss darifenacin pharmacology, adverse effects, drug interactions and much more.

CYP3A4 and CYP2D6 are important enzymes in relation to darifenacin. I breakdown the importance of these enzymes and how they can impact drug therapy.

Darifenacin has anticholinergic activity but affects the central nervous system less than other agents in its class such as oxybutynin and tolterodine.

Darifenacin’s pharmacology is selective for the Muscarinic-3 (M3) receptor in bladder tissue which helps reduce the risk for CNS adverse effects.

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