Lotrisone (Clotrimazole/Betamethasone) Pharmacology

Lotrisone is a topical cream that contains a combination of clotrimazole, an antifungal, and betamethasone dipropionate, a corticosteroid.

It is used to treat fungal skin infections such as athlete’s foot, jock itch, and ringworm that also involve inflammation or itching.

Clotrimazole works by disrupting the fungal cell membrane, while betamethasone reduces redness, swelling, and itching.

Lotrisone should not be used on the face, groin, or underarms for extended periods due to the risk of skin thinning and other steroid-related side effects.

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Isavuconazole Pharmacology

Isavuconazole is an azole antifungal that can be used for various fungal infections.

In this episode, I discuss isavuconazole pharmacology, adverse effect, drug interactions, and pharmacokinetics.

Isavuconazole is interestingly associated with QT shortening which is different from most azole antifungals that cause QT prolongation.

Oral bioavailability of isavuconazole is nearly 100% so dose conversions between IV and oral are typically not difficult to navigate.

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BCACP Study Materials

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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Pharmacy Technician Study Guide by Meded101