Prochlorperazine Pharmacology

Prochlorperazine has several potential mechanisms of action. It can block dopamine and alpha receptors as well as have anticholinergic effects.

Prochlorperazine is classified as an antipsychotic and antiemetic. It is very seldom used as an antipsychotic in clinical practice and more used for its antiemetic effects.

Because of the anticholinergic activity of prochlorperazine, there is potential for dry mouth, dry eyes, urinary retention, constipation, and other anticholinergic effects.

Prochlorperazine does have the potential to have some alpha blocking activity. Keep an eye out for hypotension in patients who may be at risk.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Ondansetron Pharmacology

Ondansetron (Zofran) is a medication used for nausea and vomiting. In this episode, I lay out the pharmacology, adverse effects, drug interactions and more!

Ondansetron has been reported to increase the risk of serotonin syndrome. I discuss this further on the podcast.

Ondansetron can exacerbate QTc prolongation. Keep an eye out for patients who may have risk factors or be on other medications that can contribute to this. I discuss this further on this podcast.

Ondansetron is often used for chemotherapy induced nausea and vomiting. I discuss this and other indications on the podcast.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Budesonide Pharmacology (Oral and Rectal Formulations)

Budesonide is a corticosteroid that can be given orally or rectally for management of Crohn’s disease or ulcerative colitis.

Because budesonide has a high first pass metabolism, the relative impact of systemic effects may be less than other steroids like prednisone.

Remember that CYP3A4 inhibitors can increase the concentrations of budesonide. I discuss this further on the podcast.

Different dosage forms of budesonide (oral versus rectal) can be used for different reasons. The site of the inflammation in Ulcerative colitis can determine which dosage form is most appropriate.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Cimetidine Pharmacology

Cimetidine blocks histamine 2 receptors which can suppress acid production and reduce symptoms of heartburn.

One of the major downsides to cimetidine is that it has a ton of drug interactions. I discuss many of the common ones in this episode.

Cimetidine is one of a few drugs that has the potential to cause gynecomastia. I discuss the mechanism of this adverse effect in this episode.

Phenytoin concentrations can rise due to the use of cimetidine. I discuss this in the drug interactions section of this episode.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Stimulant Laxatives Pharmacology

Stimulant Laxative

On this episode, I discuss the pharmacology of commonly used stimulant laxatives like sennosides and bisacodyl.

Stimulant laxatives “stimulate” the GI tract smooth muscle which helps propel fecal material out of the body and thus helping to relieve constipation.

Patients who are having diarrhea and are unsure of what medications they are taking should have their regimen assessed for these medications.

Chronic opioid therapy is a situation where chronic stimulant laxative therapy may be used.

Stimulant laxatives have very few drug interactions. However, bisacodyl effectiveness can be reduced by the use of antacids like calcium carbonate.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Metoclopramide (Reglan) Pharmacology

Metoclopramide Pharmacology

Metoclopramide can block dopamine receptors as part of it’s mechanism of action.  I discuss the clinical implications from this in the podcast.

Metoclopramide can exacerbate Parkison’s disorder so you need to be careful in that type of patient.

Metoclopramide is dosed frequently, which can potentially be a downside as far as patient adherence goes.

Metoclopramide has a few potential interactions that you should be aware of.  I talk about those in this episode.

Be sure to check out The Thrill of the Case on Amazon as I do have a clinical scenario about Reglan (metoclopramide) in that 200+ page book.

As always, check out my free Top 200 study guide!

Proton Pump Inhibitors – RLP Episode 009

Proton Pump Inhibitors are one of the most commonly used agents for heartburn and other GI disorders.  In this episode I discuss the pharmacology, adverse effects, and a couple of really common drug interactions that are often tested on.  Hope you enjoy the episode!

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