On this episode, I discuss codeine pharmacology and practical clinical practice pearls.
Codeine is metabolized by CYP2D6 to the active metabolite morphine. I discuss how this can be affected by genetics as well as other medications.
Constipation is a problem with codeine and all opioids in general. Education and making a plan with patients to combat this side effect is important.
Codeine is less potent than other opioids such as fentanyl, hydromorphone, and hydrocodone.
I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!