Category: Hematology and Immunology Medications

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Mometasone Pharmacology (Nasal and Oral Inhalation)

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Mometasone is an inhaled corticosteroid and a nasal corticosteroid. The inhaled steroid is called Asmanex by brand name and the nasal version is Nasonex.

Nasonex is primarily used in the management of allergic rhinitis and can help with nasal congestion type symptoms.

Remember that nasal mometasone takes a little while to have its full effect. It can take up to a week or two to provide its maximum benefit.

Systemic absorption of both nasal and oral inhalation mometasone is very low at less than 1%.

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Montelukast Pharmacology

Montelukast Pharmacology

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On this episode, I discuss montelukast pharmacology

Montelukast is a leukotriene receptor antagonist. Leukotrienes play an important role in causing inflammation and smooth muscle contraction in asthma and allergic rhinitis.

Because montelukast blocks the effects of leukotrienes, it can be advantageous to use this medication for allergies and asthma.

It is important to remind patients that montelukast is NOT a substitute for an acute relief medication like albuterol in the management of asthma symptoms.

Montelukast has been reported to cause mood and behavioral changes and it is important to monitor our patients for these rare concerns.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Pseudoephedrine Pharmacology

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Pseudoephedrine is commonly used to help relieve nasal congestion.

There are some adverse effects you need to be aware of with pseudoephedrine. Insomnia, increase in blood pressure, and urinary retention are all possible.

When I assess a patient using pseudoephedrine, I like to investigate blood pressure, history of urinary problems and insomnia history.

Pseudoephedrine can cause the prescribing cascade.  I lay out examples in the podcast.

Pseudoephedrine should not be utilized with MAOI’s if possible – I discuss the reason for this in the podcast.

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