Phenobarbital Pharmacology Podcast

On this episode of the Real Life Pharmacology Podcast, I cover phenobarbital pharmacology, adverse effects, important drug interactions and much more.

Phenobarbital is an enzyme inducer. It is an inducer at CYP3A4 so this can lead to numerous drug interactions.

Phenobarbital can exacerbate the risk for opioid overdose and increase the risk for respiratory depression and death.

Phenobarbital can deplete numerous vitamins such as vitamin D, folic acid, and vitamin B12. Monitoring of these is important.

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Isotretinoin Pharmacology Podcast

On this episode, I discuss isotretinoin pharmacology, side effects, drug interactions, and much more.

The iPLEDGE program is in place to ensure that pregnant patients do not receive this medication. I discuss this in more detail on this episode.

Sun sensitivity is an important adverse effect that patients should be aware of during seasons of high sun exposure.

Hepatic issues, myalgia, and psychiatric changes are rare adverse effects associated with isotretinoin.

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Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

Lovastatin Pharmacology Podcast

On this episode of the Real Life Pharmacology Podcast, I discuss lovastatin pharmacology, adverse effect, drug interactions, and more!

Lovastatin is broken down by CYP3A4 so drugs like clarithromycin, diltiazem, and others may increase concentrations.

Lovastatin is a lipophilic statin and I discuss the importance of this on the podcast.

Lovastatin has a very short half-life which means that it is ideal to dose this medication at night for maximal efficacy.

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Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

Clindamycin Pharmacology Podcast

On this podcast episode, I discuss clindamycin pharmacology, adverse effects, drug interactions, and much more!

Clindamycin (oral administration) can cause esophageal irritation and it is recommended to take this medication with a full glass of water.

C. Diff risk and frequent dosing are two of the biggest downsides to using clindamycin to manage infections.

Clindamycin has good activity against many gram-positive organisms like Staph and Strep as well as anaerobic activity.

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Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

Dextroamphetamine Pharmacology Podcast

On this podcast episode, I discuss dextroamphetamine’s pharmacology, adverse effects, drug interactions, and much more!

Dextroamphetamine is a stimulant medication. Weight loss, insomnia, tachycardia, and hypertension are all possible complications.

There is a patch dosage form of dextroamphetamine available called Xelstrym. I discuss it on this episode.

Vitamin C can reduce GI absorption of dextroamphetamine due to its ability to increase the acidity of the GI tract.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

Vardenafil Pharmacology Podcast

On this podcast episode, I discuss vardenafil pharmacology, adverse effects, drug interactions, and much more.

Vardenafil is a PDE-5 inhibitor used primarily for erectile dysfunction in males.

Using nitrates with vardenafil is contraindicated due to the risk of profound hypotension.

I have discussed how long to wait between vardenafil and nitrates in a previous post on Meded101.com.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Drug Interactions In Primary Care (Amazing Resource for Practicing Clinicians)

Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

Niacin Pharmacology Podcast

On this podcast episode, I discuss niacin pharmacology, adverse effects, drug interactions, and much more.

Niacin has historically been used to manage lipids but has fallen out of favor due to adverse effects, and newer, more effective therapies being developed.

Niacin can elevate uric acid. Be sure to use this medication cautiously in patients with gout.

Flushing is one of the most common adverse effects of niacin. High doses, immediate-release formulations, and the use of alcohol can increase the risk.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Drug Interactions In Primary Care (Amazing Resource for Practicing Clinicians)

Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

Dextromethorphan Pharmacology Podcast

I discuss dextromethorphan pharmacology, adverse effects, drug interactions, and more on this podcast episode.

CYP2D6 metabolizes Dextromethorphan. A commonly used antidepressant is a CYP2D6 inhibitor. I discuss this on the podcast.

Dextromethorphan is a commonly used OTC cough suppressant. There is potential for abuse with this medication.

In excessive doses, dextromethorphan may cause euphoria, hallucinations, and other CNS effects, but also cause cardiovascular complications.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Drug Interactions In Primary Care (Amazing Resource for Practicing Clinicians)

Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

Bexagliflozin Pharmacology Podcast

On this podcast episode, I discuss bexagliflozin pharmacology, adverse effects, drug interactions, and much more.

I wasn’t wowed by the A1C reduction of this medication. I get into the specifics on bexagliflozin in the podcast episode.

SGLT2 inhibitors like bexagliflozin increase the glucose in the urine which can facilitate the growth of bacteria and fungi in the genitourinary tract.

Limb amputation and euglycemic DKA are two rare, reported adverse effects to be aware of with the use of bexagliflozin.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Drug Interactions In Primary Care (Amazing Resource for Practicing Clinicians)

Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)

Cefuroxime Pharmacology Podcast

On this episode, I discuss cefuroxime pharmacology, adverse effects, drug interaction, pharmacokinetics, and much more.

Cefuroxime is a 2nd generation cephalosporin that binds Penicillin-binding proteins and prevents bacterial cell wall synthesis.

Medications that create a higher pH in the stomach such as antacids can ultimately reduce the concentrations of cefuroxime.

Cefuroxime is primarily eliminated by the kidney. Dose adjustments are recommended for patients with a CrCL less than 30 mls/min.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Flippin’ Pharmacology Flash Cards

Pharmacology Crossword Puzzle Book (Over 2,000 Clues/Questions!)

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BCMTMS Study Materials

Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Drug Interactions In Primary Care (Amazing Resource for Practicing Clinicians)

Perils of Polypharmacy (Great Resource for Those Who Work in Geriatrics)