Fluvoxamine Pharmacology

On this episode, I discuss fluvoxamine pharmacology, adverse effects, and most importantly, drug interactions.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Aripiprazole Pharmacology

aripiprazole pharmacology

Aripiprazole is metabolized by CYP2D6 and CYP3A4. Because of this, drug interactions can happen. I discuss specific examples in this episode.

Partial dopamine agonist activity and serotonergic activity make up a significant amount of aripiprazole’s pharmacology.

Aripiprazole is classified as an antipsychotic and can be used in schizophrenia, bipolar disorder, and depression augmentation.

Aripiprazole can cause significant akathesia. I discuss this adverse effect on this episode.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Paroxetine Pharmacology

Paroxetine (Paxil) is an SSRI that can be used in the management of depression. I discuss more on paroxetine pharmacology in this episode.

Because paroxetine has some modest anticholinergic effects, it does show up on the Beers list as a potentially inappropriate medication.

By inhibiting CYP2D6, paroxetine can have numerous drug interactions. Drugs like atomoxetine, aripiprazole, and metoclopramide can all have their concentrations increased.

Tamoxifen is activated by CYP2D6 and paroxetine can ultimately reduce the effectiveness of the medication.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Sertraline Pharmacology

Sertraline is an SSRI. It has the highest potential to cause diarrhea of any SSRI.

Sertraline is often called “Squirtraline” because of its potential to cause diarrhea.

Sertraline has a much shorter half-life than fluoxetine. I discuss why that may be important in this podcast episode.

I discuss the role of serotonin in platelet aggregation and how sertraline may affect this.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Citalopram Pharmacology

Citalopram is an SSRI used in the management of depression, anxiety, OCD, and PTSD.

How do you manage the risk of citalopram causing QTc prolongation? I discuss it further in the podcast.

Omeprazole can inhibit CYP2C19 which affects the metabolism of citalopram. I discuss the clinical impacts of this interaction in the podcast.

Geriatric dosing with citalopram is recommended to be lower than traditional adult dosing. I discuss this further in the podcast.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Fluoxetine Pharmacology

Fluoxetine is an SSRI used in the management of depression, anxiety, OCD, PTSD, and other psychiatric conditions.

Fluoxetine has a very long half-life which can impact clinical management. I discuss how this matters in this podcast episode.

Fluoxetine inhibits CYP2D6 which can alter the concentrations of many drugs.

Prodrugs like codeine and tamoxifen can have their effects reduced because of fluoxetine. I explain this further in the episode.

By inhibiting CYP2D6 concentrations of many drugs can be raised by the use of fluoxetine.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Buspirone Pharmacology

Buspirone is an anti-anxiety medication that has the potential of having some serotonin agonist activity.

Buspirone has a very high first-pass metabolism. This means that the body breaks much of the medication down prior to it getting into the systemic circulation.

Buspirone is broken down by CYP3A4, so concomitant use with inhibitors or inducers can alter its concentrations

Buspirone should not be used as needed as this medication takes a while to start to show benefit.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Trazodone Pharmacology

Trazodone pharmacology is complex. It can inhibit serotonin reuptake, block histamine receptors, and possibly have alpha-blocking activity.

Side effects of trazodone include sedation, dizziness, and dry mouth. Rarely, priapism may occur. I’ve seen this nugget come up on pharmacology exams!

While trazodone is classified as antidepressant, it is often used to help manage insomnia.

Trazodone can possibly prolong the QT interval. Risk of other medications and patient specific parameters should be considered.

Trazodone concentrations can be increased with the use of CYP3A4 inhibitors and reduced with 3A4 inducers.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!