Tag: drug interactions

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Top 200 Drugs Podcast – Medications 66-70

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Pantoprazole (Protonix) is a PPI that can be used for GERD and peptic ulcer disease. I differentiate why this medication is different from the commonly used omeprazole.

Dicyclomine (Bentyl) is an anticholinergic medication that may be used to help reduce pain and spasms associated with irritable bowel syndrome.

Sumatriptan (Imitrex) is a selective 5HT1 receptor agonist, which potentially helps with vasoconstriction that contributes to migraine symptoms.

Chlorhexidine (Peridex) is an antibiotic oral rinse that can be used for gingivitis.

Metoprolol (Lopressor, Toprol XL) is a beta-blocker that may be used for atrial fibrillation, angina prevention, and hypertension. It is not a first-line medication for hypertension.

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Top 200 Drugs Podcast – Medications 56-60

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In this episode, we highlight some of the most important clinical pearls on the following medications; nitrofurantoin, fentanyl patches, isosorbide mononitrate, fluoxetine, and triamcinolone.

Nitrofurantoin is an antibiotic used for UTIs. We need to be careful with this medication in patients with CKD.

Fentanyl is an opioid. There are many clinical quirks with fentanyl patches. For a full rundown, check out this previous podcast episode.

Isosorbide mononitrate is a nitrate medication so we need to be careful with the use of PDE-5 inhibitors.

Fluoxetine is an SSRI. It has a longer half-life than most SSRIs. I discuss what that means in this episode.

Triamcinolone (topical) is most frequently used for redness, itching, and skin irritation.

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Top 200 Drugs Podcast – Drugs 41-45

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On this episode of the Real Life Pharmacology podcast, I continue my education on the top 200 drugs. Raloxifene, prednisone, phenytoin, fish oil, and ezetimibe are covered in this podcast episode.

Prednisone is a corticosteroid that may cause hyperglycemia, insomnia, GI upset, osteoporosis, HPA suppression, and hypertension as primary adverse effects.

Raloxifene is classified as a SERM and can be used for osteoporosis and breast cancer. DVT and hot flashes are significant adverse effect concerns.

Fish oil (Lovaza) is used to reduce triglycerides. Elevated triglycerides can increase the risk of pancreatitis.

Ezetimibe inhibits the absorption of cholesterol through the gut. It lowers LDL but not to the extent of statins.

Phenytoin is a narrow therapeutic index medication (NTI) that is used as an anticonvulsant. Ataxia, confusion, GI upset, and vertical nystagmus are potential signs of toxicity.

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Top 200 Drugs Podcast – Drugs 36-40

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On this episode of the Real Life Pharmacology podcast, I continue my coverage with the Top 200 Drugs Podcast. Here’s the list of medications we will cover.

  • Lorazepam (Ativan) is a benzodiazepine well known for its anxiolytic and anti-seizure properties.
  • Phenazopyridine (Pyridium) is a urinary analgesic that can change the color of the urine to a reddish/orange color as one of its adverse effects.
  • Hydroxychloroquine (Plaquenil) is a DMARD used in rheumatoid arthritis and Lupus. One highly testable and unique nugget to remember is that it can cause retinopathy.
  • Lidocaine patch (Lidoderm) is used topically to help with various types of pain including neuropathy and postherpetic neuralgia.
  • Diclofenac (Cataflam) is an NSAID used as an analgesic and anti-inflammatory. It can increase the risk of GI bleed, edema, renal failure, and thrombosis.

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Top 200 Drugs Podcast – Drugs 21-25

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Lamotrigine is an antiseizure medication and also may be used for bipolar disorder. A rash is a major side effect to remember with this medication.

Valganciclovir is an antiviral medication that can be used to prevent cytomegalovirus (CMV) in patients with a suppressed immune system.

Fluconazole is an azole antifungal that can be used to treat candidiasis, blastomycosis, and tinea infections. Drug interactions, QTc prolongation, and hepatotoxicity are potential risks.

Atenolol is a beta-blocker used to treat atrial fibrillation and hypertension. It is relatively selective for beta-1 receptors meaning that it doesn’t affect the lungs as much as non-selective agents.

Montelukast is a medication that blocks the actions of leukotrienes. This can be beneficial for the management of allergies and asthma.

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Top 200 Drugs Pharmacology Podcast – Drugs 11-15

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Metformin is a medication used in the management of diabetes. It can cause significant diarrhea, B12 deficiency, and in rare cases, lactic acidosis.

Atorvastatin (Lipitor) is a statin medication used for cholesterol management. It lowers LDL and is associated with myopathy.

Omeprazole is a PPI used for GERD and has drug interactions with citalopram and clopidogrel.

Ciprofloxacin is a quinolone antibiotic used to treat gram-negative infections and UTIs. It carries numerous risks such as tendon rupture.

Ondansetron is an antiemetic medication used in the management of nausea and vomiting. I discuss the prescribing cascade in relation to this medication.

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Timolol Pharmacology Podcast

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On this episode, I discuss timolol pharmacology, adverse effects, drug interactions, and much more.

Timolol is a non-selective beta-blocker so it blocks both beta-1 and beta-2 receptors.

Since timolol blocks beta-2 receptors, it can blunt the effect of respiratory medications that have beta-agonist action.

Beta-blockers are notorious for causing bradycardia and pulse is an important monitoring parameter for timolol.

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Food and Supplement Drug Interactions

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On this episode of the Real Life Pharmacology Podcast, I cover some of the most common food and supplement drug interactions.

The 3 G’s can potentially increase the risk of bleeding in patients on anticoagulants and antiplatelets. I discuss what supplements these are.

There are some vitamins that can cause drug interactions. Vitamin C is a supplement that can alter the absorption of some medications.

Metal cations like iron can bind certain medications and reduce absorption. I discuss which medications are most likely to be affected.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Vonoprazan Pharmacology – New Esophagitis Medication Class! Episode 326

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On this episode, I discuss the new medication vonoprazan and where it will likely be used in practice.

Vonoprazan is from a brand new class of medication called “PCAB”. I discuss this medication and its pharmacology in this podcast episode.

Drug interactions and cost are the two major downsides of this medication that will likely limit its use compared to the PPIs.

CYP3A4 inducers like rifampin, carbamazepine, and phenytoin should not be used with vonoprazan. They will reduce the effectiveness of vonoprazan.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Top 10 Anticoagulant Drug Interactions

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Today’s sponsor of the Top 10 Anticoagulant Drug Interactions podcast is FreedAI. Freed listens, transcribes, and writes medical documentation for you.

FreedAI is offering a discount exclusive to RLP listeners! Users will get $50 off their first month with Freed! Use the discount code: RLPPOD

Apixaban is one of the most commonly used anticoagulants and there are some drug interactions you need to be aware of. Take a listen and find out!

Warfarin concentrations can substantially be elevated by drugs that inhibit CYP2C9. I cover a few of them in my top 10 anticoagulant drug interactions.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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