Tag: gout

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Gout Pharmacotherapy – Test Prep and Practice Pearls

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Gout pharmacotherapy involves more than just treating painful flare-ups. In this episode of Real Life Pharmacology, we review the most commonly used gout medications, including allopurinol, febuxostat, colchicine, probenecid, NSAIDs, and corticosteroids. Learn how these medications work, their indications, important adverse effects, clinically significant drug interactions, and practical prescribing pearls. We also discuss uric acid treatment goals, prevention of recurrent gout attacks, renal dosing considerations, and important medication safety concerns. Whether you are a pharmacist, nurse, physician, or healthcare professional preparing for a board certification exam, this episode will help strengthen your understanding of gout treatment and evidence-based gout pharmacotherapy.

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Colchicine Pharmacology

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On this episode I discuss colchicine pharmacology, adverse effects, drug interactions, and pharmacokinetics.

Colchicine ultimately works by reducing the activity of neutrophils that help contribute to pain and inflammation associated with gout.

Colchicine does have some drug interactions with medications and grapefruit juice via CYP3A4.

The most common dose limiting side effect of colchicine is diarrhea.

Colchicine can be used as a potential alternative to NSAIDs or corticosteroids in the management of a gout flare.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Probenecid Pharmacology

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Patients with G6PD deficiency who are taking probenecid are at increased risk for hemolytic anemia.

In a patient taking probenecid, they need to have adequate kidney function for the drug to work.

GI upset is likely the most common adverse effect of probenecid. It can be given with food.

Probenecid can raise the concentrations of many common antibiotics like penicillins and cephalosporins.

Remember that there are many medications that can oppose the beneficial effects of probenecid. Thiazides, niacin, and some immunosuppressants can raise uric acid.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.