Vibegron Pharmacology Podcast

On this episode of the Real Life Pharmacology podcast, I discuss vibegron pharmacology, adverse effects, drug interactions and more!

I spend some time comparing and contrasting vibegron to mirabegron. Both are beta-3 agonists used for overactive bladder.

Vibegron dosing is very simple. It is dosed once daily with no alternative dosage forms available. The starting dose is the target dose.

Being primarily excreted in the feces and urine, vibegron doesn’t have many drug interactions.

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Mirabegron Pharmacology

Mirabegron is a beta-3 agonist that can help relax bladder smooth muscle and manage symptoms of overactive bladder.

Mirabegron inhibits CYP2D6 which can negatively impact the effectiveness of tamoxifen. I discuss this in greater detail in the podcast.

Tramadol and codeine effectiveness can be impacted by mirabegron. Be aware of this when using this medication.

By inhibiting CYP2D6, mirabegron can increase the concentrations of many psychotropic medications such as fluoxetine, aripiprazole, clozapine, and paroxetine. I discuss this further in this episode of the podcast.

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