Hydromorphone Pharmacology

On this episode, I discuss hydromorphone pharmacology, adverse effect, and drug interactions.

I discuss the pharmacokinetics of hydromorphone and also discuss the relative potency compared to other opioids.

Hydromorphone drug interactions are mostly additive effects. Drugs that cause sedation or constipation can have additive effects on hydromorphone.

Be extremely careful with hydromorphone dosage forms. There are numerous different concentrations and strengths. I discuss this in this episode.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Study Materials For Pharmacists and Students

Useful Books For Any Healthcare Professional

Nursing Professionals

Dietitian Professionals

Duloxetine Pharmacology

On this episode, I discuss duloxetine pharmacology, adverse effects, and common drug interactions.

Duloxetine is an SNRI that is used for depression, anxiety, and various pain syndromes like neuropathy and fibromyalgia.

Duloxetine can inhibit CYP2D6 which can lead to higher concentrations of clozapine and propranolol and lower activity of tamoxifen.

CYP1A2 inhibitors like ciprofloxacin can raise concentrations of duloxetine leading to an increased potential for adverse effects.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Study Materials For Pharmacists and Students

Useful Books For Any Healthcare Professional

Nursing Professionals

Dietitian Professionals

Sumatriptan Pharmacology

On this episode, I discuss sumatriptan pharmacology, adverse effects, drug interactions and more.

Dosage forms can provide different methods of drug delivery and I talk about many different sumatriptan dosage forms in this episode.

Cardiovascular risks need to be assessed when using a drug like sumatriptan. I discuss this in greater detail in the podcast.

Sumatriptan has serotonergic activity and we need to assess the risk of serotonin syndrome in our patients.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Study Materials For Pharmacists and Students

Useful Books For Any Healthcare Professional

Nursing Professionals

Dietitian Professionals

Oxycodone Pharmacology

On this episode, I discuss oxycodone pharmacology, adverse effect, pharmacokinetics, and drug interactions.

Oxycodone is broken down by CYP3A4 and CYP2D6. I discuss this further on the podcast and how interactions may alter concentrations.

When a patient stops taking oxycodone after being on it for some time, you must recognize common symptoms of withdrawal.

Oxycodone comes as in an extended-release and immediate-release oral formulation.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Study Materials For Pharmacists and Students

Useful Books For Any Healthcare Professional

Nursing Professionals

Dietitian Professionals

Amitriptyline Pharmacology

On this episode, I discuss amitriptyline pharmacology, adverse effects, and drug interactions.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Study Materials For Pharmacists and Students

Useful Books For Any Healthcare Professional

Nursing Professionals

Dietitian Professionals

Phenazopyridine Pharmacology

On this episode, I discuss phenazopyridine pharmacology, adverse effects, and potential drug interactions.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Study Materials For Pharmacists and Students

Useful Books For Any Healthcare Professional

Nursing Professionals

Dietitian Professionals

Colchicine Pharmacology

On this episode I discuss colchicine pharmacology, adverse effects, drug interactions, and pharmacokinetics.

Colchicine ultimately works by reducing the activity of neutrophils that help contribute to pain and inflammation associated with gout.

Colchicine does have some drug interactions with medications and grapefruit juice via CYP3A4.

The most common dose limiting side effect of colchicine is diarrhea.

Colchicine can be used as a potential alternative to NSAIDs or corticosteroids in the management of a gout flare.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Leflunomide Pharmacology

leflunomide pharmacology

On this episode, I discuss leflunomide pharmacology. It is classified as a DMARD and is primarily used in rheumatoid arthritis.

Leflunomide carries a boxed warning for hepatoxicity. LFTs must be monitored with its use.

Leflunomide can inhibit CYP2C8 which plays an important role in pioglitazone metabolism. Concentrations of pioglitazone can go up on account of this interaction.

TB screening should be done prior to beginning the immunosuppressant leflunomide.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Baclofen Pharmacology

Baclofen is primarily used for its ability to help relieve muscle spasms. I discuss baclofen pharmacology on this podcast episode.

Baclofen should not be abruptly discontinued as it can cause a significant withdrawal reaction whose symptoms may include fever, spasticity, rhabdomyolysis, and death.

While baclofen generally avoids any issues with CYP enzyme interactions, it is eliminated by the kidney. Renal function changes can alter drug concentrations.

Sedation, confusion, dizziness, hypotension, and GI upset are some of the more common adverse effects of baclofen.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Ibuprofen Pharmacology

ibuprofen pharmacology

On this episode of the Real Life Pharmacology Podcast, I discuss ibuprofen pharmacology.

Ibuprofen can raise the concentrations of lithium and increase the risk for toxicity.

Compared to most other NSAIDs, ibuprofen has a relatively short half-life. This explains why it needs to be dosed more frequently than other agents.

Ibuprofen can contribute to renal insufficiency, GI bleed risk, and CHF exacerbations.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!