Tag: pain

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October 5, 2023October 2, 2023

Meloxicam Pharmacology Podcast

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I discuss meloxicam pharmacology, adverse effects, drug interactions, and much more on this episode of the Real Life Pharmacology Podcast.

Meloxicam tends to have a greater affinity to COX-2 versus COX-1. I discuss what this means clinically on this episode.

Important meloxicam drug interactions include anticoagulants, antiplatelet medications, renal impairing drugs, and lithium amongst others.

Meloxicam has a longer half-life than many NSAIDs and because of this can be dosed once daily for pain relief.

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September 7, 2023September 6, 2023

Etanercept Pharmacology Podcast

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On this podcast episode, I cover etanercept pharmacology, adverse effects, drug interactions and much more.

Etanercept is classified as a DMARD but is different from older DMARDs in that it is a biologic agent and needs to be injected.

Vaccination assessment in patients is important prior to initiating etanercept due to the fact that the medication may blunt the effectiveness of the vaccines.

Immunosuppression from etanercept can lead to an increased risk for infection and malignancy.

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August 24, 2023August 20, 2023

Pregabalin Pharmacology Podcast

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On this podcast episode, I discuss (Lyrica) pregabalin pharmacology, adverse effects, drug interactions, and much more.

I compare pregabalin and gabapentin in this episode and one important difference is the percent absorption of gabapentin compared to pregabalin.

Pregabalin can exacerbate the risk of respiratory depression and overdose in patients who are taking opioids.

Pregabalin is most frequently used in practice for neuropathic pain syndromes.

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November 10, 2022November 9, 2022

Gabapentin (Neurontin) Pharmacology Podcast

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On this podcast episode, I discuss gabapentin (Neurontin) pharmacology, adverse effects, drug interactions, and much more!

Gabapentin’s GI absorption is a little wacky. I discuss on the podcast the clinical effects that this may have on our patients.

Renal elimination is critical to gabapentin. Worsening renal function will significantly impact the action of the drug.

CNS sedation can be a problem with gabapentin, especially in combination with other CNS depressants. I discuss this further on the podcast.

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January 13, 2022January 10, 2022

Hydromorphone Pharmacology

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On this episode, I discuss hydromorphone pharmacology, adverse effect, and drug interactions.

I discuss the pharmacokinetics of hydromorphone and also discuss the relative potency compared to other opioids.

Hydromorphone drug interactions are mostly additive effects. Drugs that cause sedation or constipation can have additive effects on hydromorphone.

Be extremely careful with hydromorphone dosage forms. There are numerous different concentrations and strengths. I discuss this in this episode.

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January 6, 2022January 10, 2022

Duloxetine Pharmacology

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On this episode, I discuss duloxetine pharmacology, adverse effects, and common drug interactions.

Duloxetine is an SNRI that is used for depression, anxiety, and various pain syndromes like neuropathy and fibromyalgia.

Duloxetine can inhibit CYP2D6 which can lead to higher concentrations of clozapine and propranolol and lower activity of tamoxifen.

CYP1A2 inhibitors like ciprofloxacin can raise concentrations of duloxetine leading to an increased potential for adverse effects.

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December 23, 2021January 10, 2022

Sumatriptan Pharmacology

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On this episode, I discuss sumatriptan pharmacology, adverse effects, drug interactions and more.

Dosage forms can provide different methods of drug delivery and I talk about many different sumatriptan dosage forms in this episode.

Cardiovascular risks need to be assessed when using a drug like sumatriptan. I discuss this in greater detail in the podcast.

Sumatriptan has serotonergic activity and we need to assess the risk of serotonin syndrome in our patients.

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December 9, 2021January 10, 2022

Oxycodone Pharmacology

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On this episode, I discuss oxycodone pharmacology, adverse effect, pharmacokinetics, and drug interactions.

Oxycodone is broken down by CYP3A4 and CYP2D6. I discuss this further on the podcast and how interactions may alter concentrations.

When a patient stops taking oxycodone after being on it for some time, you must recognize common symptoms of withdrawal.

Oxycodone comes as in an extended-release and immediate-release oral formulation.

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October 28, 2021January 10, 2022

Amitriptyline Pharmacology

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On this episode, I discuss amitriptyline pharmacology, adverse effects, and drug interactions.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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