Furosemide Pharmacology

On this episode, I discuss furosemide pharmacology and its ability to promote fluid loss.

I discuss conversion to other diuretics and between IV and oral furosemide.

Drug interactions are possible with furosemide and the most common interaction is an increased risk of renal impairment with drugs like NSAIDs.

Hypokalemia can be dramatic with furosemide and potassium supplementation is often necessary.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Study Materials For Pharmacists and Students

Useful Books For Any Healthcare Professional

Nursing Professionals

Dietitian Professionals

Hydroxyzine Pharmacology

Hydroxyzine is an older, first-generation antihistamine that has significant anticholinergic properties. On this episode, I discuss hydroxyzine pharmacology and clinical pearls.

Itching, pain, anxiety, and insomnia are all common uses for hydroxyzine.

Be aware of patients with gastroparesis or BPH as hydroxyzine can worsen these conditions.

CNS depressant and anticholinergic drug interactions are the most common types of interaction with hydroxyzine.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Study Materials For Pharmacists and Students

Useful Books For Any Healthcare Professional

Nursing Professionals

Dietitian Professionals

Vitamin B12 Pharmacology

On this episode, I cover clinical tips and practice pearls surrounding vitamin B12 pharmacology.

Vitamin B12 deficiency plays a critical role in the development of macrocytic anemia.

There are medications that you have to be aware that can deplete vitamin B12. Metformin, colchicine, and PPIs are some common examples.

A lack of intrinsic factor can lead to B12 deficiency. Intrinsic factor is necessary for adequate GI absorption of vitamin B12.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Study Materials For Pharmacists and Students

Useful Books For Any Healthcare Professional

Nursing Professionals

Dietitian Professionals

Ketamine Pharmacology

On this episode, I discuss ketamine pharmacology.

Ketamine is primarily broken down by CYP2B6 which fortunately does not have a lot of common medications that can interfere with its action.

Ketamine can cause psychiatric type adverse effects such as hallucinations, nightmares, and vivid dreams.

At lower to moderate dosages, ketamine does have some mild sympathetic activity which can raise blood pressure and heart rate.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Topiramate Pharmacology

On this episode of the Real Life Pharmacology Podcast, I cover topiramate pharmacology.

Topiramate is indicated for migraine prevention, seizures, and weight loss which are the most common uses that I see this medication used for.

Topiramate has carbonic anhydrase activity, so rarely, use of this drug may induce metabolic acidosis.

By far, the most common patient complaint I get with the use of topiramate is that it causes cognitive slowing or impairment.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Colchicine Pharmacology

On this episode I discuss colchicine pharmacology, adverse effects, drug interactions, and pharmacokinetics.

Colchicine ultimately works by reducing the activity of neutrophils that help contribute to pain and inflammation associated with gout.

Colchicine does have some drug interactions with medications and grapefruit juice via CYP3A4.

The most common dose limiting side effect of colchicine is diarrhea.

Colchicine can be used as a potential alternative to NSAIDs or corticosteroids in the management of a gout flare.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Fexofenadine Pharmacology

Fexofenadine is a 2nd generation antihistamine that is primarily used for allergic rhinitis. I cover fexofenadine pharmacology on this podcast episode.

Fruit juices can actually impair the absorption of fexofenadine and increase the risk of treatment failure.

Fexofenadine is mildly anticholinergic but overall has low to no CNS penetration.

Because fexofenadine has low CNS penetration, the risk for sedation and dizziness is much lower than older antihistamines like diphenhydramine.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Empagliflozin Pharmacology

On this episode I discuss empagliflozin pharmacology and how this medication lowers blood sugar.

Empagliflozin is associated with an increased risk of genitourinary tract infections.

Be aware that patients who are prone to hypotension, may have an increased risk of this issue with empagliflozin use.

Empagliflozin has cardiovascular and renal function benefits in addition to its blood sugar lowering effects.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Rifaximin Pharmacology

On this episode, I discuss rifaximin pharmacology.

Rifaximin is most commonly used in hepatic encephalopathy and C. difficile infection.

Rifaximin systemic absorption is minimal so that is why it is primarily only used for GI conditions.

Drug interactions with rifaximin are fairly minimal compared to its cousin rifampin which has tons of drug interactions.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Naproxen Pharmacology

On this episode of the Real Life Pharmacology Podcast, I discuss naproxen pharmacology.

Naproxen can raise the concentrations of lithium and increase the risk for toxicity.

Compared to most other NSAIDs, naproxen tends to have a lower cardiovascular risk.

Naproxen can contribute to renal insufficiency, GI bleed risk, and CHF exacerbations.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!