Category: Infectious Disease and Oncology Medications

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Linezolid Pharmacology

linezolid pharmacology

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Linezolid is an antibiotic used for bacterial infection. It primarily works by inhibiting bacterial protein synthesis.

Linezolid is primarily bacteriostatic against most bacteria which means that it inhibits the growth and doesn’t necessarily kill the bacteria itself.

Caution must be used with linezolid and serotonergic drugs as there is a risk for serotonin syndrome. Clinical risk/benefit analysis needs to be done.

Linezolid overall has good coverage for VRE and MRSA. It is an option for MRSA pneumonia where daptomycin is not.

Linezolid has both an oral and an IV option which allows for good continuity of inpatient and outpatient use.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Nitrofurantoin Pharmacology

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On this episode I breakdown nitrofurantoin pharmacology. Nitrofurantoin is an antibiotic that is used in the treatment of UTI’s.

Nitrofurantoin has activity by creating reactive metabolites that can disrupt protein synthesis and ultimately kills the bacteria causing the infection.

It is important to remember with nitrofurantoin, that in the setting of systemic infection and/or kidney involvement, the drug may not be very effective.

Nitrofurantoin can potentially reduce the effectiveness of certain vaccines. Be sure to look this up prior to administration.

Nitrofurantoin can cause pulmonary symptoms as well as neuropathy. This is very important to monitor for.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Quinolone Antibiotic Pharmacology

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Quinolones are a class of antibiotics that can be used for various infections. I discuss the pharmacology, adverse effects, drug interactions and other items on this podcast episode.

On this episode, I talk about the warnings associated with quinolones.

Quinolone use has subsided over time, not due to the fact that they are ineffective, but to rising concerns and warnings about adverse effects.

Quinolones can interact with quite a few medications.  I’ve seen a case of amiodarone and levofloxacin contributing to QTc prolongation which I discuss on this episode.

It is critical to remember the binding interactions associated with quinolones as these can potentially lead to treatment failure.

Enjoy the show and be sure to snag your FREE 31 page PDF on the top 200 drugs, a gift simply for following the podcast!

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Tetracyclines Pharmacology Episode 038

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On this episode, I discuss how the tetracyclines impact bacterial protein synthesis.

I also remind you of several medications that fall in the tetracycline class.  Doxycycline is by far the medication I see used the most.

You’ll also learn about common side effects like GI upset and photosensitivity.

I cover why this class of medication is typically avoided in pediatrics and pregnancy.

I hope you enjoy the show and don’t forget to snag your FREE 31 page PDF study guide!

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Sulfamethoxazole and Trimethoprim RLP Episode 026

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On this episode, I discuss sulfamethoxazole and trimethoprim. We cover mechanism of action, adverse effects, and some really important, clinically relevant drug interactions.  Hope you enjoy the show and be sure to take advantage of our FREE 31 page PDF document on the highly testable pearls of the Top 200 Drugs.  A great resource for any nursing, pharmacy, or midlevel, or med student!

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Aminoglycoside Pharmacology Episode 006

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On this episode, I will discuss aminoglycoside pharmacology.  Gentamicin and tobramycin are the two classic examples of aminoglycosides.  We will review how these medication work in the body, adverse effects, and the importance of pharmacokinetics and laboratory monitoring.

All subscribers to the website/podcast will get access to a FREE Top 200 Drug Study Guide where I highlight the 3 most highly testable pearls from each medication (this is a 31 page PDF!)  In addition, you’ll get a free 100 question pharmacology test.  Both resources are free, simply for following the podcast!  What are you waiting for? Click Here to Subscribe