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Colestipol is a bile acid sequestrant that can be used in the management of hyperlipidemia.
By binding bile acid in the gut, colestipol can lower LDL that is bound to bile acid by eliminating it through the feces.
Numerous drug interactions existed as colestipol can bind many drugs. This is a downside to its use and why it isn’t a preferred hyperlipidemia agent.
In patients with elevated triglycerides, colestipol should be avoided.
I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.