On this episode, I cover pioglitazone pharmacology. The primary mechanism of action with pioglitazone is that it is an agonist at Peroxisome
Two common side effects exist with pioglitazone. This drug can cause weight gain and also contribute to edema.
Pioglitazone has a boxed warning and is contraindicated in patients who have symptomatic heart failure.
There are a few potential interactions with pioglitazone. Trimethoprim and gemfibrozil can inhibit the breakdown of pioglitazone.
A couple of advantages of pioglitazone include that it is generic (inexpensive) and that it is dosed once daily.
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