The Serotonin and Norepinephrine Reuptake Inhibitors are a class of medication used for various mental health disorder and pain syndromes. I talk about the pharmacology of the SNRI’s and how it relates to their adverse effect profile. The pharmacology of SNRI’s also plays an important role in why they are efficacious for treatment of pain compared to the SSRI’s. In addition to the adverse effects, I will outline some common drug interactions and which medications might be affected by the SNRI’s. Enjoy the episode and I hope you pick up some clinical practice pearls with the SNRI’s! Don’t forget to take advantage of our free giveaway as well, nearly 1,000 healthcare professionals and students have already done so!