Podcast: Play in new window | Download (Duration: 11:20 — 16.1MB) | Embed
Subscribe: Google Podcasts | Stitcher | RSS | More
Tizanidine is primarily broken down by CYP1A2. Ciprofloxacin can inhibit CYP1A2 and cause higher tizanidine concentrations.
Tizanidine has a similar classification as clonidine. Pay attention to adverse effects like hypotension and bradycardia.
When patients taking routine tizanidine stop taking it, there is potential for a discontinuation syndrome that may lead to rebound hypertension.
Dry mouth and CNS depression are common adverse effects of tizanidine.
I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!